Associations of serum cotinine with asthma risk in US children: a mediation analysis of body mass index
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View abstract on PubMed
Summary
This summary is machine-generated.Elevated serum cotinine, a biomarker for tobacco exposure, significantly increases childhood asthma risk. Body mass index (BMI) partially mediates this association, highlighting a critical link between environmental factors and pediatric respiratory health.
Area Of Science
- Environmental Health
- Pediatric Pulmonology
- Biomarkers
Background
- Childhood asthma prevalence is rising, with tobacco smoke exposure as a key factor.
- The precise impact of tobacco exposure on pediatric asthma requires further investigation.
- Serum cotinine serves as a reliable biomarker for tobacco exposure.
Purpose Of The Study
- To investigate the association between serum cotinine levels and childhood asthma risk.
- To determine if body mass index (BMI) mediates the relationship between tobacco exposure and asthma.
- To analyze data from the National Health and Nutrition Examination Survey (NHANES) for children aged 3-12 years.
Main Methods
- Utilized NHANES data (2011-2018) including serum cotinine, physician-diagnosed asthma, and BMI.
- Employed weighted multivariable logistic regression, subgroup analyses, and smooth curve fitting.
- Conducted threshold effect and mediation analyses to explore the relationship.
Main Results
- A nonlinear relationship was observed between serum cotinine and asthma risk.
- Asthma risk saturation occurred at a Log2-serum cotinine value of -0.3 (0.81 ng/mL).
- Body mass index (BMI) accounted for approximately 12.21% of the mediating effect between cotinine and asthma risk.
Conclusions
- Elevated serum cotinine is significantly linked to increased childhood asthma risk.
- Body mass index (BMI) plays a significant mediating role in this association.
- This study underscores the importance of tobacco exposure biomarkers and BMI in pediatric asthma.
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