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Controlling Enzymatic Degradation of Carboxyl-Modified Chitosan and Hyaluronic Acid Biopolymers Using Dynamic
Wasitha P D W Thilakarathna1, Emma G Welshman1, Namita Bhasin1,2
1Department of Biomaterials & Applied Oral Sciences, Dalhousie University, Halifax, Nova Scotia B3H 4R2, Canada.
Abstract:
The enzymatic degradation of hyaluronic acid (HA) and carboxyl-modified chitosan (CC) polymers in aqueous dispersions can be controlled by dynamic covalent cross-linking. Unlike un-cross-linked HA, dynamic covalent cross-linking preserves the viscoelastic behavior of HA dispersions when exposed to hyaluronidase enzyme. Among the dynamic covalent cross-linked CC dispersions, only dispersions with degrees of deacetylation of 98% (CC98) partially upheld the viscoelastic behavior under lysozyme-mediated degradation. Overall, our results suggest that dynamic covalent cross-linking can produce injectable HA and CC dispersions with partial enzymatic degradation resistance.
