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Juvenile systemic lupus erythematosus: Challenge for equity in Latin America

Ana Victoria Villarreal-Treviño1, Claudia Saad-Magalhãnes2, Marcela Álvarez3

  • 1Profesoradscrito a Reumatología Pediátrica en el Hospital Universitario "Dr. José E. González", Monterrey, Nuevo León, Mexico.

Reumatologia Clinica
|November 14, 2025
PubMed

Insights

Juvenile-onset systemic lupus erythematosus (jSLE) is more severe in Latin America, with limited data and access to care. Region-specific strategies are crucial for early diagnosis and improved outcomes in children with jSLE.

Area of Science:

  • Pediatric Rheumatology
  • Autoimmune Diseases
  • Public Health in Latin America

Background:

  • Juvenile-onset systemic lupus erythematosus (jSLE) exhibits greater severity and morbidity compared to adult-onset SLE.
  • Limited epidemiological and clinical data exist for jSLE in the Latin American region.
  • Access to specialized pediatric rheumatology care is scarce, causing diagnostic delays and treatment barriers.

Purpose of the Study:

  • To review the current status of jSLE in Latin America.
  • To highlight the need for region-specific strategies for jSLE management.
  • To advocate for improved early diagnosis and access to care for pediatric lupus patients.

Main Methods:

  • Literature review of jSLE in Latin America.
  • Analysis of incidence, prevalence, and clinical phenotypes.
  • Assessment of healthcare access and disparities.

Main Results:

  • Significant gaps in data regarding jSLE incidence, prevalence, and phenotypes in Latin America.
  • Concentration of specialized care in limited centers, impacting timely diagnosis and treatment.
  • Disparities in outcomes for children and adolescents with jSLE across the region.

Conclusions:

  • Urgent need for region-specific strategies to address jSLE in Latin America.
  • Improving early diagnosis and expanding access to specialized care are critical.
  • Reducing disparities in outcomes for pediatric lupus patients requires focused interventions.

Keywords:
Cultural diversityDiferencias en saludDiversidad culturalEthnicityEtnicidadFactores socioeconómicoHealth care systemsHeath disparitiesJuvenile systemic lupus erythematosus in Latin AmericaLupus eritematoso sistémico juvenil en América LatinaSistemas de saludSocioeconomic factors

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