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Updated: Jan 11, 2026

CO2-Lasertonsillotomy Under Local Anesthesia in Adults
Published on: November 6, 2019
Failures of Local Anesthesia: Dental Perspective
Kainat Anjum1, Karpagavalli Shanmugasundaram2, John Moran1
1Clinical Preceptee, Rutgers School of Dental Medicine, Newark, NJ 07103, USA.
Abstract:
This review discusses the most prevalent factors causing local anesthesia (LA) failures in dentistry, ranging from operator error to systemic conditions. Various pharmacologic, inflammatory, and psychological factors contributing to LA failure have been discussed. Knowledge about updated evidence on anesthetic agents, block techniques, anatomic variations such as bifid canals and accessory innervation, and the role of patient-specific factors, including systemic conditions and anxiety, is also explored. Strategies for prevention of anesthetic failure have also been discussed.
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