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Glioneuronal and Neuronal Tumors in Adults: World Health Organization 2021 Imaging and Molecular Updates
Melissa B Warstadt1, Tyler J Richards2, Lubdha M Shah1
1From the Department of Radiology (M.B.W., T.J.R., L.M.S., K.L.S.), University of Utah, Salt Lake City, Utah.
Abstract:
Glioneuronal and neuronal tumors are defined histologically by the presence of mixed glial and neuronal elements in the case of glioneuronal tumors, and by neuronal elements in the case of neuronal tumors. In 2021, the World Health Organization (WHO) published the latest edition of a CNS tumor classification and added 3 new glioneuronal tumors, as well as further delineated histologic, immunohistochemical, and molecular markers associated with the diagnosis of these tumors. This review aims to highlight the key updated features of glioneuronal and neuronal tumors in adults based on the fifth edition of the WHO Classification of Central Nervous System Tumors by clinical and epidemiological presentation, imaging appearance, and pathology.
