The impact of urine pH on lithogenic risk profile in children with urolithiasis
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View abstract on PubMed
Summary
This summary is machine-generated.Maintaining a urine pH between 6.75 and 7.0 is crucial for pediatric stone formers. This pH range supports protective factors like citrate and magnesium, aiding in stone prevention.
Area Of Science
- Pediatric Nephrology
- Urology
- Metabolic Disorders
Background
- Urinary pH impacts lithogenic substance solubility and excretion, but its metabolic associations in pediatric stone formers are not well understood.
- This study examines the link between urinary pH and metabolic risk factors in children and adolescents with urolithiasis.
Purpose Of The Study
- To investigate the association between urinary pH and various lithogenic risk factors in pediatric stone formers.
- To compare these associations with those in healthy pediatric controls.
Main Methods
- A cohort of 400 pediatric stone formers (ages 3-18) and 372 healthy controls underwent 24-h urine collection.
- Analyzed urinary pH, BMI z-score, urine volume, osmolality, creatinine, GFR, and excretion of calcium, oxalate, phosphate, magnesium, citrate, and uric acid.
- Evaluated two lithogenic risk indices: Bonn Risk Index (BRI) and Upper Metastable Limit osmolality (UMLOsm).
Main Results
- Pediatric stone formers showed higher urine volume, oxalate, calcium, ionized calcium, uric acid, and BRI than controls.
- Controls had higher urinary citrate, osmolality, and UMLOsm.
- Lower urine pH correlated with higher BMI z-scores and reduced urine volume; calcium excretion peaked at pH 7, while citrate and magnesium increased between pH 6.75-7.0.
Conclusions
- Individualized dietary and lifestyle advice is essential for pediatric stone formers.
- Recommendations include maintaining a healthy BMI, adequate hydration, and a urine pH between 6.75 and 7.0.
- This pH range appears to promote protective factors like citrate and magnesium, potentially reducing stone recurrence.
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