Application of an individualized nomogram in the first-trimester for predicting cleft lip and palate
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View abstract on PubMed
Summary
This summary is machine-generated.A new nomogram model accurately predicts fetal cleft lip and palate (CLP) in the first trimester using nuchal translucency, crown-rump length, and facial markers. This non-invasive tool enhances early CLP detection for better management.
Area Of Science
- Medical Imaging
- Fetal Medicine
- Genetics
Background
- Cleft lip and palate (CLP) is a common congenital anomaly with significant health and economic impacts.
- Early detection of CLP is crucial for timely intervention and improved outcomes.
Purpose Of The Study
- To develop and validate an individualized nomogram model for predicting fetal CLP in the first trimester.
- To incorporate fetal nuchal translucency thickness (NT), crown-rump length (CRL), and facial profile markers into the predictive model.
Main Methods
- A cohort of singleton pregnancies underwent first-trimester screening (11-14 weeks).
- Fetal NT, CRL, frontomaxillary facial angle (FMFA), and inferior facial angle (IFA) were measured via ultrasound.
- A nomogram model was developed using feature selection and multivariable analysis, with performance evaluated using ROC and PR curves.
Main Results
- The nomogram model achieved an AUC of 0.847, significantly outperforming individual markers (FMFA, IFA, NT, CRL).
- The model demonstrated high accuracy (0.977) and specificity (0.999), with good sensitivity (0.482).
- Calibration and decision curve analyses confirmed the model's clinical utility and good predictive agreement.
Conclusions
- The integrated nomogram model shows superior diagnostic performance for first-trimester CLP prediction compared to individual markers.
- This practical, non-invasive tool facilitates early CLP detection, aiding in prenatal management and family counseling.
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