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Updated: Jan 11, 2026

Modeling Mitochondrial Disease Using Brain Organoids: A Focus on Mitochondrial Encephalomyopathy, Lactic Acidosis, and Stroke-like Episodes
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Animal models of methylmalonic acidemia: insights and challenges

Shan Shan1, Min Liu1,2, Yue Ma2

  • 1Medical Research Center, Jinan Maternity and Child Care Hospital Affiliated to Shandong First Medical University, Jinan, 250000, China.

Orphanet Journal of Rare Diseases
|November 14, 2025
PubMed

Keywords:
Animal modelsInherited metabolic diseasesMethylmalonic acidemiaPathogenesisTherapeutic strategies

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