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Updated: Jan 11, 2026

Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Human metapneumovirus: pathogenesis, epidemiology, diagnostic technologies, and potential intervention strategies
Guicai Gao1, Ruihong Lin1, Dongli Ma2
1Institute of Paediatrics, Shenzhen Children's Hospital, Shenzhen, 518026, Guangdong Province, China.
Abstract:
Human metapneumovirus (HMPV) is a notable viral pathogen that is responsible for respiratory tract infections in infants, young children, elderly individuals, and immunocompromised individuals. Particularly in the post-COVID-19 era, HMPV has gradually surpassed other respiratory viruses and continues to pose a threat to human health. While substantial progress has been made in understanding the mechanisms of HMPV infection in the host, as well as in terms of diagnostic and prevention methods, no effective vaccines or specific antiviral drugs against HMPV have yet been approved. In this review, we summarize the structure of HMPV and its pathogenic mechanisms; discuss the molecular epidemiology and diagnostic techniques related to HMPV; and summarize the latest advances in the prevention and treatment of HMPV infections, particularly the development of neutralizing antibodies, vaccines, and antiviral drugs. Finally, we discuss the prospects and challenges that lie ahead for HMPV research and clinical interventions.
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