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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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Different Pattern in Circulating MicroRNA-22-3p Levels Between Patients With Primary Versus Secondary Sarcopenia.

Mirela Vatic1,2, Anselm A Derda3,4, Tania Garfias-Veitl1,2,5

  • 1Department of Cardiology and Pneumology, University Medical Center Göttingen, Goettingen, Germany.

Aging Cell
|November 15, 2025
PubMed
Summary
This summary is machine-generated.

Circulating microRNA-22 (miR-22) levels show diagnostic potential for primary sarcopenia in older adults and secondary sarcopenia in heart failure patients. This suggests miR-22 as a novel epigenetic biomarker for skeletal muscle dysfunction.

Keywords:
heart failuresarcopeniaskeletal muscle

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Area of Science:

  • Biochemistry
  • Genetics
  • Gerontology

Background:

  • Sarcopenia, a decline in muscle mass and strength, is categorized as primary (aging-related) or secondary (disease-related).
  • MicroRNA-22 (miR-22) plays a crucial role in regulating muscle differentiation and function.
  • Identifying reliable biomarkers for sarcopenia is essential for early diagnosis and intervention.

Purpose of the Study:

  • To investigate the diagnostic value of circulating miR-22 levels in patients with primary and secondary sarcopenia.
  • To assess the association between miR-22 expression and sarcopenia in distinct cohorts.

Main Methods:

  • Serum miR-22 levels were quantified using quantitative real-time PCR in participants from the SPRINTT study (primary sarcopenia) and SICA-HF study (secondary sarcopenia).
  • Multivariate analyses were employed to determine the independent predictive value of miR-22 for sarcopenia.
  • Clinical and functional parameters were compared between sarcopenic and non-sarcopenic individuals.

Main Results:

  • In the SPRINTT cohort, lower miR-22 levels were independently associated with primary sarcopenia.
  • In the SICA-HF cohort, miR-22 levels were significantly associated with secondary sarcopenia in heart failure patients.
  • Sarcopenic individuals in both cohorts exhibited poorer physical function compared to non-sarcopenic individuals.

Conclusions:

  • Circulating miR-22 levels are significantly associated with both primary and secondary sarcopenia.
  • miR-22 demonstrates potential as a novel epigenetic biomarker for detecting skeletal muscle dysfunction.
  • Further research is warranted to validate miR-22 as a clinical diagnostic tool for sarcopenia.