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Updated: Jan 11, 2026

Human Liver Microphysiological System for Assessing Drug-Induced Liver Toxicity In Vitro
Published on: January 31, 2022
Molecular Pathways Involved in Drug-Induced Hepatotoxicity: A Mini Review
Annu Bhati1, Avijit Mazumder1, Priyanka Bansal1
1Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Knowledge Park-II, Greater Noida, Uttar Pradesh 201306, India.
Abstract:
Drug-induced hepatotoxicity (DIH) poses a significant clinical challenge due to its unpredicta-ble nature and diverse manifestations. The liver, with its central role in metabolism and close association with the gastrointestinal tract, is particularly susceptible to drug-induced toxicity. DIH encompasses a spectrum of liver injuries, including hepatocellular, cholestatic, and mixed patterns, which may increase the risk of other liver diseases. This review examines diverse examples and molecular mechanisms under-lying DIH, highlighting the influence of genetic predisposition, drug interactions, and pre-existing liver conditions. Given the complexity and variability of hepatotoxic responses to numerous medications, un-derstanding these mechanisms is crucial for improving the diagnosis and management of DIH.
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