Feline leukemia and RD-114 virus group-specific proteins: comparison of amino terminal sequence

The major internal virion polypeptide from feline and RD-114 type C viruses has been subjected to amino terminal sequence analyses with the Beckman automated sequencer. These proteins, as well as their homologs in rat and mouse viruses, begin with the sequence prolylleucylarginyl (Pro-Leu-Arg). Virus RD-114 differs from conventional feline type C viruses that show about 80 percent relatedness based on calculation of the minimum number of base changes to give equivalent coding for the protein segments analyzed. In addition, insertion of a gap in the RD-114 sequence is necessary to maintain positional homology. The difference between RD-114 and feline leukemia virus appears as great as the difference between mouse type C viruses and either of these two viruses. Thus, even though current evidence suggests that RD-114 is of feline origin, the sequence differences between RD-114 and conventional feline virus group-specific proteins is well beyond that based on one or a few point mutations.