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Updated: Jan 11, 2026
Investigating Intestinal Inflammation in DSS-induced Model of IBD
Published on: February 1, 2012
Associations of coagulation function indicators and intestinal function impairment markers with clinical outcomes in
Jing Ma1, Fan Yang2, Gaifeng Liu3
1Department of Critical Care Medicine, Guyuan People's Hospital, Guyuan 756000, Ningxia Hui Autonomous Region, China.
Background:
Sepsis, a systemic inflammatory response to acute infections.
Objective:
We aimed to explore the associations of coagulation function indicators and intestinal function impairment markers with clinical outcomes in septic patients with gastrointestinal dysfunction.
Methods:
Subjects (n=105) were selected from septic patients with gastrointestinal dysfunction treated between January 2022 and December 2024. Detection of coagulation function indicators [platelets (PLT), fibrinogen (Fib), and D-dimer (D-D)] and intestinal function impairment markers [endotoxin (ET) and d-lactate (d-Lac)] was completed on the day of admission. Patients were divided into two groups based on their 28 day survival status (dead or alive): a group of patients that died and survival group.
Results:
The APACHE II score, SOFA score, D-D and d-Lac were influencing factors of clinical outcomes (P<0.05). The sensitivity and specificity of Fib, D-D, ET and d-Lac alone and their combination for predicting death were 67.44%, 74.42%, 81.40%, 65.17% and 77.74%, and 75.81%, 74.19%, 67.74%, 75.81% and 83.87%, respectively, and the areas under the curves were 0.737, 0.815, 0.779, 0.748 and 0.868, respectively (P<0.05).
Conclusion:
The coagulation function indicators and intestinal function impairment markers have associations with the clinical outcomes in septic patients with gastrointestinal dysfunction.
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