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Multi-Platform analytics integration for clinical trial Recruitment: A digital health informatics implementation

Melissa L Kramer1, Aileen K Ho2, Emil Lamprecht3

  • 1University of Reading, School of Psychology and Clinical Language Sciences, University of Reading, Harry Pitt Building, Earley Gate, Reading RG6 7BE, United Kingdom; Live UTI Free Ltd, Suite 7, The Courtyard, Carmanhall Rd, Sandyford, Dublin D18NW62, Ireland.

International Journal of Medical Informatics
|November 15, 2025
PubMed
Summary

A new informatics framework improves clinical trial recruitment using multi-channel digital campaigns and analytics. This approach significantly exceeded industry benchmarks for click-through rates, enhancing patient enrollment strategies.

Keywords:
Analytics integrationClinical trial methodologyDigital health informaticsDigital recruitmentHealth social networksMulti-platform tracking

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Area of Science:

  • Digital health informatics
  • Clinical trial management
  • Health informatics

Background:

  • Clinical trial recruitment faces significant challenges, with high termination rates due to low enrollment.
  • Standardized digital recruitment frameworks using health informatics are underdeveloped.
  • Referral partnerships and multi-platform analytics offer solutions but lack systematic implementation.

Purpose of the Study:

  • To demonstrate a structured methodology for implementing and measuring multi-channel digital recruitment campaigns for clinical trials.
  • To integrate analytics platforms and referral partnerships for optimized clinical trial outreach.

Main Methods:

  • A six-month multi-channel digital recruitment campaign was conducted for two Phase III clinical trials (May-October 2022).
  • Campaign utilized seven channels including mass emails, website announcements, browser notifications, Instagram, and email automations.
  • An integrated analytics platform tracked performance with real-time optimization using direct and indirect funnel architectures.

Main Results:

  • The integrated analytics framework tracked 4829 clicks across seven channels, achieving a 2.79% click-through rate (CTR).
  • This CTR substantially exceeded clinical trial banner advertisement benchmarks (0.1-0.3%) and healthcare Facebook ad standards (0.83%).
  • Website announcements (52.54%) and mass emails (28.00%) generated the highest volume of clicks.

Conclusions:

  • A replicable informatics framework for analytics-driven digital clinical trial recruitment campaigns is presented.
  • The methodology shows how to integrate analytics and referral partners to optimize outreach.
  • This approach achieves performance substantially above industry benchmarks for clinical trial recruitment.