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Updated: Jan 11, 2026
Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
Published on: July 29, 2022
Characterization and function analysis of the peritrophin-1 in Penaeus vannamei post-WSSV infection
Fanghui Fu1, Bingbing Yang2, Qian Xue2
1Shanghai Ocean University, National Experimental Teaching Demonstration Center of Fisheries Science, Shanghai, 201306, China; State Key Laboratory of Mariculture Biobreeding and Sustainable Goods, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao, Shandong, 266071, China.
Abstract:
Peritrophin, a classical chitin-binding protein, is thought to play a key role in the immunity of insects and crustaceans. In the present study, we identified a peritrophin-1 homolog from Penaeus vannamei, designated as PvPT1. PvPT1 contains a 672-bp open reading frame (ORF) encoding a 223-amino-acid protein with three chitin-binding domain 2 (ChtBD2) domains. Its expression was upregulated upon white spot syndrome virus (WSSV) challenge. 16 SNPs within the PvPT1 DNA sequence were discovered. Silencing PvPT1 via dsRNA suppressed WSSV replication, increased shrimp survival rates after WSSV infection, and modulated the expression of genes involved in the apoptotic pathway, antiviral response, cellular stress response, anti-lipopolysaccharide factors (ALFs), and the phenoloxidase (PO) family. These results suggest that PvPT1 may play a role in WSSV infection in P. vannamei.
