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Author Spotlight: Decoding Mitochondrial Aging
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Decoding aging through nitrogen containing compounds: A nutrigenomic insight
Spandana Rajendra Kopalli1, Nitu L Wankhede2, Sushruta Koppula3
1Department of Bioscience and Biotechnology, Sejong University, Gwangjin-gu, Seoul, 05006, Republic of Korea.
Molecular and Cellular Neurosciences
|November 15, 2025
Summary
Nitrogen compounds are vital for healthy aging by regulating gene expression and cellular functions. Optimizing nitrogen metabolism through nutrigenomics can enhance health span and mitigate age-related decline.
Area of Science:
- Nutrigenomics
- Molecular Biology
- Aging Research
Background:
- Nitrogen compounds are crucial for human nutrition and health.
- They regulate gene expression, cellular signaling, and metabolic pathways.
- These processes are essential for maintaining health during aging.
Purpose of the Study:
- To review the role of nitrogen compounds in aging.
- To explore the implications of nitrogen nutrigenomics for health span.
- To highlight therapeutic potential for mitigating age-related decline.
Main Methods:
- Literature review integrating historical and contemporary research.
- Analysis of nitrogen metabolism's impact on cellular processes.
- Examination of interactions with nutrient-sensing pathways and epigenetic regulators.
Main Results:
- Nitrogen compounds like amino acids and nitric oxide are key to protein synthesis, mitochondrial function, and oxidative stress management.
- Disruptions in nitrogen metabolism accelerate cellular aging and increase susceptibility to age-related diseases.
- Nitrogen compounds interact with mTOR, AMPK, and epigenetic regulators influencing DNA repair, autophagy, and inflammation.
Conclusions:
- Optimizing nitrogen metabolism offers therapeutic potential for enhancing health span.
- Nitrogen nutrigenomics presents opportunities for targeted nutritional strategies.
- Further research into nitrogen compounds can lead to innovative interventions for longevity and well-being.
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