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Updated: Jan 11, 2026

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Longitudinal prevalence of perioperative neurocognitive disorders in older surgical patients: A multicenter

Tony Tan1, Ellene Yan2, Yasmin Alhamdah1

  • 1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada; Department of Anesthesia and Pain Medicine, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON, Canada.

Anaesthesia, Critical Care & Pain Medicine
|November 15, 2025
PubMed
Abstract

No abstract available in PubMed .

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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