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Preparation of cobalt porphyrin-based covalent organic framework doped poly(deep eutectic solvent-co-ethylene glycol
Wenjun Wang1, Hui Lyu1, Caisa Xiao1
1Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, Hubei Key Laboratory for Precision Synthesis of Small Molecule Pharmaceuticals, College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, PR China.
Background:
Estrogens are representative endocrine-disrupting chemicals that enter the environment through various pathways and pose detrimental impacts to human health even at low concentrations. Therefore, the highly sensitive detection of estrogens in complex environmental samples is crucial.
Results:
A cobalt porphyrin-based covalent organic framework (Co-Por-COF) doped polymer monolithic column for pipette tip micro-solid phase extraction (PT-μSPE) of estrogens was prepared using deep eutectic solvent composed of choline chloride (ChCl) and itaconic acid (IA) as the functional monomer and ethylene glycol dimethacrylate (EGDMA) as the crosslinking agent. After the extraction conditions were optimized, a PT-μSPE-high performance liquid chromatography (HPLC) method was established for the detection of 6 estrogens in soil. This method demonstrated a wide linear range (5-500 ng g-1) (R2 > 0.9995), low limits of detection (0.5-1.0 ng g-1, S/N = 3) and high precision (RSDs <8.5 %), providing a reliable technique for the detection of trace estrogens in soil.
Significance:
The Co-Por-COF doped poly (ChCl-IA-co-EGDMA) monolithic column exhibited good adsorption selectivity for estrogens. During the polymerization reaction, ChCl-IA effectively enhanced the dispersibility of Co-Por-COF, thereby improving the doping uniformity. Moreover, the doped Co-Por-COF enhanced the adsorption performance of the monolithic column for estrogens.
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