Jove
Visualize
Contact Us

Related Concept Videos

JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Upper Egyptian Outcome Of Kasai Portoenterostomy In Biliary Atresia: A Cross-sectional Retrospective Study.
  1. Home
  3. Upper Egyptian Outcome Of Kasai Portoenterostomy In Biliary Atresia: A Cross-sectional Retrospective Study.

Related Experiment Video

Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma
09:19

Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma

Published on: July 14, 2022

4.1K

Upper Egyptian outcome of Kasai portoenterostomy in biliary atresia: A cross-sectional retrospective study.

Sarah Magdy Abdelmohsen1, Ahmed Soliman2, Mohamed Fathy3

  • 1Aswan University Hospital, Aswan University, Aswan City, Egypt.

Pediatrics and Neonatology
|November 15, 2025

View abstract on PubMed

Summary
This summary is machine-generated.

Kasai portoenterostomy (KPE) improves survival rates for infants with biliary atresia (BA). Early jaundice clearance after KPE surgery is achievable and can be predicted by liver enzyme levels, even with delayed diagnoses.

Keywords:
CholangitisCholestasisNeonatal jaundiceShort-term outcomeSurvival with native liverUpper Egypt

More Related Videos

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
07:44

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

6.5K
Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision
05:36

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision

Published on: May 2, 2025

597

Related Experiment Videos

Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma
09:19

Robotic Taj Mahal Hepatectomy for Hilar Cholangiocarcinoma

Published on: July 14, 2022

4.1K
Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction
07:44

Endoscopic Ultrasound-Guided Biliary Drainage: Endoscopic Ultrasound-Guided Hepaticogastrostomy in Malignant Biliary Obstruction

Published on: March 25, 2022

6.5K
Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision
05:36

Laparoscopic Common Bile Duct Exploration Followed by Primary Suture Using a Modified Bile Duct Incision

Published on: May 2, 2025

597

Area of Science:

  • Pediatric Surgery
  • Hepatology
  • Clinical Outcomes Research

Background:

  • Biliary atresia (BA) is a severe neonatal liver disease requiring prompt surgical intervention.
  • Kasai portoenterostomy (KPE) is the standard surgical procedure for BA, aiming to restore bile flow.
  • The timing of KPE is critical for improving outcomes in infants with BA.

Purpose of the Study:

  • To evaluate the short-term outcomes of Kasai portoenterostomy (KPE) in infants diagnosed with biliary atresia (BA).
  • To assess the impact of patient age and other factors on KPE success in Upper Egypt.
  • To identify predictors of successful jaundice clearance and survival post-KPE.

Main Methods:

  • A retrospective, cross-sectional, multicenter study was conducted in Upper Egypt.
  • Data from 45 infants with BA who underwent KPE between January 2019 and September 2021 were analyzed.
  • Collected data included demographics, clinical presentation, surgical details, and postoperative outcomes, including jaundice clearance and survival.

    • Main Results:

    • The mean age at KPE was 99 days; 64.4% achieved jaundice clearance within 12.3 weeks.
    • 57.8% of patients survived with their native livers during a five-year follow-up period.
    • A significant decrease in alkaline phosphatase (ALP) in the first postoperative week predicted a good outcome (cutoff 560 U/L). Parental smoking was prevalent in 95.5% of cases.

    Conclusions:

    • Kasai portoenterostomy (KPE) is a vital procedure for biliary atresia (BA) infants, enhancing native liver survival regardless of age at operation.
    • Postoperative AST, ALP, and GGT levels can predict jaundice clearance, with dramatic declines by the third postoperative month.
    • Despite delayed diagnoses in this cohort, KPE yielded favorable outcomes, highlighting the need for targeted interventions to improve early detection.