Bone density, structure, and estimated strength in children with congenital heart disease. A CHAMPS* cohort study
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View abstract on PubMed
Summary
This summary is machine-generated.Children with congenital heart disease (CHD) exhibit poorer bone structure in their limbs compared to typically developing peers (TDP). Complex CHD lesions are linked to significantly worse bone density, structure, and strength, increasing fracture risk.
Area Of Science
- Pediatric Orthopedics
- Cardiology
- Bone Biology
Background
- Children with congenital heart disease (CHD) often have reduced physical activity, lower birth weights, and poorer nutrient intake.
- These factors increase the risk of impaired skeletal development in children with CHD compared to typically developing peers (TDP).
Purpose Of The Study
- To assess and compare bone architecture in children with CHD versus TDP.
- To evaluate differences in bone parameters based on CHD lesion complexity.
Main Methods
- Peripheral quantitative computed tomography (pQCT) scans of the radius and tibia were performed on 42 children with CHD and 41 TDP (ages 7-15).
- Bone parameters were analyzed using MANCOVA, controlling for sex, age, height, weight, maturity, and physical activity.
Main Results
- No significant differences in distal bone parameters were found between CHD and TDP groups.
- Children with CHD showed significantly lower total area, cortical content, cortical area, cortical thickness, and polar stress-strain index at the radial and tibial shaft compared to TDP.
- Complex CHD lesions were associated with significantly worse bone parameters and greater cortical density at the radial and tibial shaft compared to TDP.
Conclusions
- Children with complex CHD demonstrate poorer bone architecture at the radial and tibial shaft compared to TDP.
- Complex CHD lesions may elevate the risk of impaired bone density, structure, and estimated strength, potentially increasing fracture risk.
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