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Updated: Jan 11, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
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Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing

Published on: July 5, 2019

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Prevalence and molecular landscape of NRG1 fusions in Japanese solid tumors: a nationwide data analysis using the

Masaki Ishida1, Tadaaki Yamada2, Ryo Tsunashima3

  • 1Department of Pulmonary Medicine, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465, Kajii-cho, Kamigyo-ku, Kyoto 602-8566, Japan; Department of Cancer Genome Medical Center, Kyoto Prefectural University of Medicine, Kajii-cho, Kamigyo-ku, Kyoto, Japan.

Lung Cancer (Amsterdam, Netherlands)
|November 16, 2025
PubMed
Abstract

Insights

Neuregulin 1 (NRG1) gene fusions are rare oncogenic drivers, primarily found in lung cancer. The CD74 gene is the most common fusion partner in these NRG1 fusion-positive advanced solid tumors.

Area of Science:

  • Oncology
  • Genomics
  • Molecular Biology

Background:

  • Neuregulin 1 (NRG1) gene fusions are key drivers of ERBB pathway activation in various solid tumors.
  • Understanding the epidemiology and clinicogenomics of NRG1 fusion-positive cancers is crucial for advancing targeted therapies.

Purpose of the Study:

  • To investigate the prevalence and clinicogenomic landscape of NRG1 fusions in Japanese patients with advanced solid tumors.
  • To identify common fusion partners and co-occurring genomic alterations in NRG1 fusion-positive cancers.

Main Methods:

  • Retrospective analysis of 95,149 patients with advanced solid tumors from a Japanese database (June 2019 - February 2025).
  • Comprehensive genomic profiling to identify NRG1 fusions, fusion partners, and co-occurring alterations.
  • Evaluation of tumor mutational burden, microsatellite instability, and clinical characteristics.

Main Results:

  • NRG1 fusions were identified in 29 (0.03%) of 95,149 patients, predominantly in lung cancer (0.30%).
  • CD74 was the most frequent fusion partner (82.4%) in lung cancers with NRG1 fusions.
  • Co-occurring alterations in CDKN2A, CDKN2B, and MTAP were common (69.0%), and mucinous adenocarcinoma was noted in 17.6% of lung cancers.

Conclusions:

  • NRG1 fusions are rare but significantly associated with lung cancer, often involving the CD74 fusion partner.
  • This nationwide study provides the most extensive analysis of NRG1 fusions in Japanese patients with advanced solid tumors.
Keywords:
Comprehensive genomic profiling assaysNRG1 fusionNon–small cell lung cancerPrecision oncology

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