Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Central Dogma01:20

The Central Dogma

31.6K
The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
In the early 1900s, scientists discovered that DNA stores all the information needed for cellular functions and that proteins perform most of these functions. However, the mechanisms of converting genetic information into functional proteins remained unknown for many years. Initially, it was believed that a single gene is...
31.6K
The Central Dogma01:25

The Central Dogma

138.9K
Overview
138.9K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

14.6K
Ribosome synthesis is a highly complex and coordinated process involving more than 200 assembly factors. The synthesis and processing of ribosomal components occurs not only in the nucleolus but also in the nucleoplasm and the cytoplasm of eukaryotic cells.
Ribosome biogenesis begins with the synthesis of 5S and 45S pre-rRNAs by distinct RNA polymerases. The primary transcripts are extensively processed and modified before they are bound and folded by ribosomal proteins and assembly factors,...
14.6K
Ribosomal RNA Synthesis02:53

Ribosomal RNA Synthesis

4.1K
4.1K
Types of RNA01:20

Types of RNA

9.0K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
9.0K
Types of RNA01:23

Types of RNA

72.5K
Overview
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in the regulation of gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA...
72.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Activity-regulated circSamm50 modulates mitochondrial dynamics and spine structural plasticity.

Cell reports·2026
Same author

Intellectual disability-causing mutations in KIF11 impair microtubule dynamics and dendritic arborization.

Nature communications·2026
Same author

PKA orchestrates long-range lysosomal vesicle transport during synaptic maintenance.

iScience·2025
Same author

lncRNA ADEPTR loss-of-function elicits sex-specific behavioral and spine deficits.

iScience·2025
Same author

The lncRNA Gas5 is an activity-responsive scaffold that mediates cAMP-dependent synaptic plasticity.

Science signaling·2025
Same author

Decoding the complex journeys of RNAs along neurons.

Nucleic acids research·2025

Related Experiment Video

Updated: Jan 11, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

24.7K

Noncoding RNAs orchestrating the central dogma.

Sebastian Lozano-Villada1, Sathyanarayanan V Puthanveettil1

  • 1Department of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, Jupiter, Florida, USA.

The Journal of Biological Chemistry
|November 16, 2025
PubMed
Summary

Noncoding RNAs (ncRNAs) are crucial regulators of gene expression, moving beyond their past perception as transcriptional noise. Understanding these complex RNA networks is key to deciphering cellular specialization and plasticity, especially in the nervous system.

Keywords:
RNA functionRNA modificationscentral dogmagene regulationmolecular biologyneuronsnon-coding RNA

More Related Videos

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

14.0K
Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution
10:53

Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution

Published on: January 16, 2017

9.5K

Related Experiment Videos

Last Updated: Jan 11, 2026

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster
09:39

Enhanced Northern Blot Detection of Small RNA Species in Drosophila Melanogaster

Published on: August 21, 2014

24.7K
Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation
12:54

Real-time Analysis of Transcription Factor Binding, Transcription, Translation, and Turnover to Display Global Events During Cellular Activation

Published on: March 7, 2018

14.0K
Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution
10:53

Isolation of Cognate RNA-protein Complexes from Cells Using Oligonucleotide-directed Elution

Published on: January 16, 2017

9.5K

Area of Science:

  • Molecular Biology
  • Genetics
  • Cellular Regulation

Background:

  • Noncoding RNAs (ncRNAs) were historically dismissed as transcriptional noise.
  • Emerging evidence highlights ncRNAs as critical regulators of gene expression, influencing cellular functions.
  • This necessitates a reevaluation of the central dogma of molecular biology.

Purpose of the Study:

  • To review the critical roles of ncRNAs in cellular function.
  • To discuss the challenges in understanding ncRNA mechanisms of action.
  • To explore the view of ncRNAs as components of dynamic regulatory networks.

Main Methods:

  • Literature review focusing on ncRNA functions and regulatory networks.
  • Emphasis on the nervous system as a model for ncRNA-mediated regulation.
  • Discussion of outstanding questions in ncRNA research.

Main Results:

  • ncRNAs act as scaffolds, catalysts, and regulators, impacting gene expression.
  • ncRNAs form integrated, dynamic regulatory networks with spatiotemporal constraints.
  • These networks are adaptable to cellular demands and physiological signals.

Conclusions:

  • ncRNA-mediated regulation is fundamental to cellular specialization and plasticity.
  • The nervous system serves as a key model for studying ncRNA functions.
  • Deciphering ncRNA interactions reveals new dimensions of genetic code interpretation.