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Related Concept Videos

Hematopoiesis01:21

Hematopoiesis

8.6K
The process of blood cell formation is called hematopoiesis. Hematopoiesis starts early during development, on the seventh day of embryogenesis. This phase of hematopoiesis is called the primitive wave, wherein the extraembryonic yolk sac allows the production of erythroid cells and endothelial cells from a common precursor called hemangioblast. The erythroid cells provide oxygen to support the growth of the rapidly dividing embryo. Hemangioblasts later develop into hematopoietic stem cells or...
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Overview of Hematopoiesis01:20

Overview of Hematopoiesis

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Hematopoiesis, or blood cell production, is a vital biological process that begins early in embryonic development and continues throughout life. This process generates the various types of cells found in blood, including red blood cells, white blood cells, and platelets from hematopoietic stem cells (HSCs).
Developmental Phases of Hematopoiesis
Initially, HSCs are formed in the embryonic yolk sac, a critical site for early blood cell production. These stem cells subsequently migrate to other...
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Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

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All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
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Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

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Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
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Reporter Genes02:11

Reporter Genes

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Reporter genes are a type of protein-coding gene that are often tagged to a gene of interest. Once inside a target cell, reporter genes usually produce visually identifiable characteristics like fluorescence and luminescence when expressed along with the gene of interest. Thus, reporter genes “report” the presence or absence of genes of interest in an organism, determine the gene expression pattern, or track the physical location of a DNA segment or protein in the cell.
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Lineage Commitment01:21

Lineage Commitment

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Commitment is the  process whereby stem cells:
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Related Experiment Video

Updated: Jan 11, 2026

Combining Intravital Fluorescent Microscopy IVFM with Genetic Models to Study Engraftment Dynamics of Hematopoietic Cells to Bone Marrow Niches
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Gene Expression Imaging in Hematopoiesis.

Justin C Wheat1, Robert A Coleman2, Ulrich Steidl3

  • 1Department of Hematology and Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

Journal of Molecular Biology
|November 16, 2025
PubMed
Summary

Hematopoiesis research uses imaging and single-cell analysis to understand blood cell development from stem cells. Novel technologies are advancing this field, revealing intricate regulatory mechanisms.

Keywords:
cell fategene expressionimagingsingle-molecule resolutiontranscription

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Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
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Identification of Key Factors Regulating Self-renewal and Differentiation in EML Hematopoietic Precursor Cells by RNA-sequencing Analysis
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Area of Science:

  • Hematology
  • Stem Cell Biology
  • Molecular Biology
  • Quantitative Microscopy
  • Systems Biology

Background:

  • Hematopoiesis, the process of blood production, is a key model for stem cell research due to accessible samples and functional assays.
  • A central question is how diverse blood cell types originate from a common pool of hematopoietic stem cells.
  • Understanding gene expression and regulation is crucial for elucidating cell differentiation pathways.

Purpose of the Study:

  • To review the historical contributions of imaging techniques to hematopoiesis research.
  • To discuss emerging areas and innovative technologies transforming the study of blood production.
  • To identify future challenges in the field of hematopoiesis research.

Main Methods:

  • Review of historical imaging techniques in hematopoiesis research.
  • Integration of quantitative microscopy and systems biology approaches.
  • Application of single-cell analysis techniques to resolve cellular heterogeneity.

Main Results:

  • Single-cell analysis has been instrumental in resolving heterogeneity in hematopoietic regulation.
  • Advances in quantitative microscopy and systems biology are revolutionizing molecular biology and hematopoiesis research.
  • Novel technologies are leading to significant progress in understanding blood production mechanisms.

Conclusions:

  • Imaging has historically played a vital role in developing heuristics for hematopoiesis research.
  • Innovative technologies are opening exciting new avenues for exploring blood production.
  • Addressing future challenges will be critical for continued advancements in understanding hematopoiesis.