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Effect of Pre- and Post-thermocycling Strontium Infiltration on Cracks and Tubular Structure in Human Root Dentin
Salvator Napoli1, Ho Chein-Chao2, Mina Shekarian3
1Biomaterial and Prosthodontics Laboratory, Department of Restorative Dentistry, Rutgers School of Dental Medicine, Newark, New Jersey; Department of Endodontics, University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, California; Department of Biomedical Engineering, Rutgers University, New Brunswick, New Jersey.
Introduction:
This study aimed to evaluate the effect of topical application of strontium under thermocycling conditions on average crack length, crack density, tubular density, and tubular diameter in both healthy and diabetic root dentin.
Methods:
Sixty mid-root dentin discs from extracted premolars (n = 30 healthy, n = 30 diabetic) were allocated to 6 groups: no Sr treatment (CTL), Sr treatment before thermocycling (Sr-PRE), or Sr after thermocycling (Sr-POST) for both metabolic conditions. Sr treatment involved a 5-minute application of 1.8 μM L-ascorbic acid-2-phosphate strontium solution. All specimens underwent 2000 thermal cycles (5°C-55°C). Scanning electron microscopy was used to assessed average crack length, crack density, tubule density, and tubule diameter. Data were analyzed using two-way ANOVA (metabolic status × Sr regimen; α = 0.05) using GraphPad Prism software (10.5.0.774 version; GraphPad Software, San Diego, CA).
Results:
Diabetic dentin exhibited significantly greater crack growth (P < .05) and tubule density (P < .05) after thermocycling compared to healthy controls. Sr-PRE reduced crack growth by approximately 70% in diabetic dentin and 56% in healthy dentin (P < .05), significantly lowering tubule density and diameter. Sr-POST provided intermediate protection. Sr's protective effects were most pronounced in diabetic dentin.
Conclusions:
A brief chairside Sr rinse applied before thermal stress markedly reduced crack metrics and tubule density/diameter relative to controls after thermocycling.
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