Age-related attenuation of the fast visuomotor network during rapid goal-directed reaching

Humans can react remarkably quickly to novel or displaced visual stimuli when time is of the essence. Such movements are thought to be initiated by a subcortical fast visuomotor network, but it is unclear how this network declines with age. Past work in the upper limb has detailed delayed reaching corrections to jumped visual stimuli in aging, but the underlying mechanisms contributing to these changes of the fast visuomotor network are poorly understood. Conversely, work in the lower limb has reported delayed muscle recruitment during obstacle avoidance, but such findings may be confounded by age-related challenges in postural control. The output of the fast visuomotor network can be quantified by measuring express visuomotor responses (EVRs), which are the earliest and very short-latency bursts of muscle activity following visual target presentation. Here, we compare EVR prevalence, latency, and magnitude in 16 elderly (58-80 years old, 8 female) and 22 younger (18-25 years old, 15 female) participants performing visually-guided reaches. We also investigated the impact of postural stability by having participants reach either while seated on a stable chair, or on a wobble stool. Both elderly and younger cohorts expressed EVRs, but EVRs in the elderly were comparatively less frequent, and had longer latencies and smaller magnitudes. Postural instability had no effects on these outcomes. Our results suggest age-related declines in the fast visuomotor network, potentially resulting from deterioration of underlying circuits and a prioritization of stability over speed. This study serves as an important standard for future research investigating clinical populations.