Related Experiment Video
Updated: Jul 4, 2026
Assessment of Cardiac Function and Myocardial Morphology Using Small Animal Look-locker Inversion Recovery SALLI MRI in Rats
Published on: July 19, 2013
Effect of the Modified Look-Locker Inversion Recovery Sampling Scheme on Accuracy and Heart Rate Variability in
Yuta Endo1, Keita Fukushima2, Akihito Nakanishi2
1Department of Medical Radiological Technology, Faculty of Health Sciences, Kyorin University, Mitaka, Tokyo, Japan.
Abstract:
This study aimed to clarify the accuracy and variability of heart rate variability effects on T1 relaxation time values acquired using different sampling schemes of the modified Look-Locker inversion recovery (MOLLI) method. Five MOLLI sampling schemes-5(3)3, 5s(3s)3s, 4(1)3(1)2, 4s(1s)3s(1s)2s, and 3(3)3(3)5-were compared using a simulated electrocardiogram signal in a phantom experiment. The 5(3)3 and 5s(3s)3s schemes demonstrated high accuracy across the range of native and contrast-enhanced T1 values, with correlation coefficients exceeding 0.95 compared with the reference T1. Regarding heart rate variability, the 5(3)3 scheme showed minimal variation in the measured value across different heart rates, regardless of the T1 value, with an error rate below 6% relative to the reference T1. Therefore, the 5(3)3 scheme can achieve highly accurate measurements over a wide T1 range and is robust against heart rate variability.
