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Multimodality Imaging in Hypertrophic Cardiomyopathy

Matthew Peters1, McKenzie Schweitzer2, Patrycja Galazka1

  • 1Aurora Cardiovascular and Thoracic Services, Aurora Sinai/Aurora St. Luke's Medical Centers, Aurora Health Care, 2801 West Kinnickinnic River Parkway, Suite 130, Milwaukee, WI 53215, USA; Department of Cardiovascular Medicine, Wake Forest University School of Medicine, 2900 West Oklahoma Avenue, Milwaukee, WI 53215, USA.

Cardiology Clinics
|November 16, 2025
PubMed

Insights

Accurate imaging is crucial for diagnosing and managing hypertrophic cardiomyopathy (HCM). Advanced techniques like echocardiography, MRI, CT, and nuclear imaging improve risk assessment, monitoring, and treatment guidance for HCM patients.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Genetics

Background:

  • Hypertrophic cardiomyopathy (HCM) is a complex genetic heart disease.
  • Accurate diagnosis and management of HCM are essential for patient outcomes.
  • Traditional imaging methods have limitations in fully characterizing HCM.

Purpose of the Study:

  • To review the current role of various imaging modalities in HCM.
  • To highlight the complementary nature of different imaging techniques.
  • To discuss emerging innovations in HCM imaging.

Main Methods:

  • Review of current literature on advanced cardiovascular imaging.
  • Analysis of echocardiography, cardiac magnetic resonance (CMR), computed tomography (CT), and nuclear imaging in HCM.
  • Discussion of technological advancements and their clinical impact.

Main Results:

  • Echocardiography provides foundational assessment of HCM.
  • CMR offers superior tissue characterization and volumetric analysis.
  • CT and nuclear imaging provide complementary information for specific clinical questions.
  • Integrated imaging approaches enhance diagnostic accuracy and risk stratification.

Conclusions:

  • Multimodality imaging is indispensable for comprehensive HCM evaluation.
  • Advances in imaging are crucial for personalized risk assessment and therapy.
  • Future innovations promise further refinement in HCM diagnosis and management.

Keywords:
Cardiac CTCardiac magnetic resonanceEchocardiographyHypertrophic cardiomyopathyMultimodality imagingNuclear imaging

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