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Related Experiment Video

Updated: Jun 15, 2026

Development of a Lateral Flow Immunochromatographic Strip for Rapid and Quantitative Detection of Small Molecule Compounds
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Electrically Readable Lateral Flow Assay Using Organic Transistors for Diagnostic Applications.

María Jesús Ortiz-Aguayo1, Carme Martínez-Domingo1,2, Diego Gutiérrez1

  • 1Institut de Ciència de Materials de Barcelona, ICMAB-CSIC, Campus UAB, Bellaterra, 08193, Spain.

Advanced Materials (Deerfield Beach, Fla.)
|November 17, 2025
PubMed
Summary
This summary is machine-generated.

This study presents a novel, reusable biosensor integrating electrolyte-gated organic field-effect transistors (EGOFETs) with paper fluidics for rapid, portable diagnostics. The device achieves high sensitivity and selectivity for Human Immunoglobulin G detection at the point-of-care.

Keywords:
biosensorelectrolyte‐gated organic field‐effect transistorlateral flow assayorganic transistor, point‐of‐care

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Electrolyte-gated organic field-effect transistors (EGOFETs) offer ultrasensitive, label-free biosensing capabilities.
  • Current limitations include microfluidic challenges and complex assays, hindering portable diagnostic applications.
  • Paper-based lateral flow (LF) immunoassays are relevant for point-of-care (PoC) diagnostics but suffer from low detection sensitivity.

Purpose of the Study:

  • To develop a simple, reusable, and portable biosensor by integrating EGOFETs with LF paper fluidics.
  • To create a cost-effective PoC diagnostic test with rapid results for Human Immunoglobulin G (IgG) detection.
  • To overcome the limitations of existing biosensing technologies for integrated diagnostics.

Main Methods:

  • Fabrication of an EGOFET sensor integrated with paper-based lateral flow fluidics.
  • Validation of the biosensor for Human Immunoglobulin G detection.
  • Development of a portable prototype with a miniaturized electronic reader connected to a smart device.

Main Results:

  • Achieved rapid detection results within approximately 20-30 minutes.
  • Demonstrated a wide linear range, high selectivity, and excellent reproducibility for Human Immunoglobulin G detection.
  • Reported a low limit of detection of 0.1 femtomolar (fm) for Human Immunoglobulin G.

Conclusions:

  • The integrated EGOFET-LF system provides a reusable, portable, and cost-effective solution for PoC diagnostics.
  • This technology fulfills the need for low-cost PoC tests and advances digital lateral flow assays.
  • The developed system offers a promising foundation for next-generation integrated diagnostic platforms.