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Updated: Jan 11, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Dual Proton/Anion Binding Through Reciprocal Allostery in Platinum(II) Lantern-Shaped Cages
Zack T Avery1, Elizabeth C Elphick1, Michael G Gardiner1
1Research School of Chemistry, Australian National University, Canberra, ACT, 2601, Australia.
None:
Reciprocal allosteric regulation, where binding events influence each other simultaneously, is a key target for supramolecular chemists designing biomimetic systems. Platinum(II) lantern-shaped cages, formed from a series of ligands bearing central protonatable sites of varied basicity through rational tuning of the backbone, featured nuanced dual action host-guest chemistry. This reveals the first example of reciprocal allostery in a supramolecular system, between protonation and anion binding. Switching studies were conducted using acid/base and silver/chloride stimuli, with single and multi-anion systems.
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