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Updated: Jan 6, 2026

Live Imaging of Antifungal Activity by Human Primary Neutrophils and Monocytes in Response to A. fumigatus
Published on: April 19, 2017
In Vitro Activity of Nitroxoline (5-Nitro-8-Hydroxyquinoline) Against Aspergillus Species
Ada Hoffmann1, Oliver A Cornely2,3,4,5, Jana Vonhoegen1
1Institute for Medical Microbiology, Immunology and Hygiene (IMMIH), Medical Faculty and University Hospital of Cologne, University of Cologne, Cologne, Germany.
Background:
Nitroxoline is an old antibiotic currently approved for the treatment of uncomplicated urinary tract infections. Its mode of action is based on the chelation of bivalent cations, such as zinc.
Objectives:
As zinc plays a central role in the metabolism of Aspergillus spp., we performed antifungal susceptibility testing against Nitroxoline using broth microdilution.
Methods:
Overall, 13 Aspergillus isolates were tested according to the EUCAST guidance document (Guinea et al. EUCAST, def. doc. 9.4, 2022) including two genetically proven Azole-resistant strains.
Results:
The overall Minimal Inhibitory Concentration (MIC)50/90 was 0.5 mg/L.
Conclusions:
These results correspond to excellent in vitro activity against Aspergillus spp.
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