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Triglyceride-Glucose Index and the Risk of Calcific Aortic Valve Stenosis: A Bidirectional Mendelian Randomization

Xuecheng Song1,2, Xinghong Lin1, Xin Xu1

  • 1Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou City, China

Anatolian Journal of Cardiology
|November 17, 2025
PubMed

Insights

This study found that a higher triglyceride-glucose (TyG) index causally increases the risk of calcific aortic valve stenosis (CAVS). This highlights the TyG index as a potential biomarker for CAVS development.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Syndrome
  • Genetic Epidemiology

Background:

  • Calcific aortic valve stenosis (CAVS) is a prevalent valvular heart disease linked to metabolic and inflammatory issues.
  • The triglyceride-glucose (TyG) index, a marker for insulin resistance and inflammation, is associated with cardiovascular diseases.
  • The causal link between the TyG index and CAVS requires further investigation.

Purpose of the Study:

  • To investigate the potential causal relationship between the triglyceride-glucose (TyG) index and calcific aortic valve stenosis (CAVS).
  • To utilize bidirectional Mendelian randomization (MR) to assess this association.

Main Methods:

  • Employed two-sample and multiple Mendelian randomization (MR) analyses using genome-wide association study data.
  • Utilized inverse variance weighted (IVW), MR-Egger, and weighted median methods for robust association testing.
  • Performed sensitivity analyses to detect horizontal pleiotropy and confirm findings.

Main Results:

  • A significant causal effect was found: a 1-unit increase in the TyG index was associated with a 1.50-fold increased risk of CAVS.
  • Sensitivity analyses confirmed the robustness of the findings and indicated no significant horizontal pleiotropy.
  • Multiple MR analyses, adjusting for confounders, reinforced the significant association (OR = 1.64).

Conclusions:

  • This Mendelian randomization study provides strong evidence for a causal effect of a higher triglyceride-glucose (TyG) index on the risk of calcific aortic valve stenosis (CAVS).
  • The findings suggest the TyG index may serve as a valuable biomarker for predicting CAVS risk.
Abstract

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