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A Multicenter Study of Systemic Inflammatory Biomarkers for Prognostic Evaluation in iCCA Patients
Yun Tao1, Benjie Xu2, Jie Tang1
1Department of Intervention, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, People's Republic of China.
The pan-immune-inflammation value (PIV) is a superior prognostic biomarker for intrahepatic cholangiocarcinoma (iCCA) compared to traditional inflammatory markers. This readily available indicator aids in predicting patient survival outcomes.
Area of Science:
- Oncology
- Immunology
- Biomarker Discovery
Background:
- Prognostic value of systemic inflammatory biomarkers in intrahepatic cholangiocarcinoma (iCCA) is uncertain.
- Need to identify the most effective predictive indicator for iCCA patient outcomes.
Purpose of the Study:
- Compare the predictive performance of twelve systemic inflammatory biomarkers in iCCA.
- Identify the most effective biomarker for predicting overall survival (OS) and disease-free survival (DFS) in iCCA patients.
Main Methods:
- Retrospective analysis of 312 iCCA patients undergoing curative resection.
- Assessment of twelve systemic inflammatory biomarkers for OS and DFS prediction.
- Evaluation of prognostic accuracy using C-index, time-AUC, and Brier score; development of nomograms.
Main Results:
- Pan-immune-inflammation value (PIV) showed the strongest prognostic performance among all biomarkers.
- High PIV independently predicted poor OS and DFS (P < 0.001).
- Nomograms integrating PIV with clinicopathological factors improved survival prediction accuracy.
Conclusions:
- PIV offers superior, cost-effective prognostic value for iCCA compared to traditional indices.
- PIV is a readily available biomarker for iCCA prognosis.
- Prospective validation of PIV in external cohorts is warranted.
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