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Expert Opinion: Management of Intraocular Inflammation and Vasculitis After Intravitreal Pegcetacoplan for Geographic Atrophy.

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Short-Term Changes in Intraocular Pressure Following Intravitreal Injection of Pegcetacoplan.

Bita Momenaei1, Taku Wakabayashi1, Olufemi E Adams1

  • 1Wills Eye Hospital, Mid Atlantic Retina, Thomas Jefferson University, Philadelphia, PA, USA.

Journal of Vitreoretinal Diseases
|November 17, 2025
PubMed
Summary

Intravitreal pegcetacoplan injections for geographic atrophy cause a temporary spike in intraocular pressure (IOP). IOP levels returned to near baseline within 30 minutes, with higher baseline IOP or glaucoma history linked to elevated post-injection IOP.

Keywords:
Syfovreage-related macular degenerationgeographic atrophyintraocular pressurepegcetacoplan

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Area of Science:

  • Ophthalmology
  • Retinal Diseases
  • Pharmacology

Background:

  • Geographic atrophy (GA) is an advanced form of age-related macular degeneration.
  • Intravitreal injections are a common treatment modality for various retinal conditions.
  • Understanding the immediate safety profile of new treatments is crucial.

Purpose of the Study:

  • To assess short-term changes in intraocular pressure (IOP) following intravitreal pegcetacoplan injections.
  • To evaluate the safety and IOP dynamics after pegcetacoplan administration for GA.

Main Methods:

  • Prospective, interventional case series study.
  • Patients with GA received intravitreal pegcetacoplan (0.1 mL).
  • Intraocular pressure (IOP) was measured pre-injection and at multiple time points up to 30 minutes post-injection using a handheld tonometer.

Main Results:

  • A significant, transient increase in IOP was observed immediately post-injection (mean 40.2 mmHg).
  • IOP gradually decreased to near pre-injection levels within 30 minutes (mean 16.4 mmHg).
  • Higher pre-injection IOP and a history of glaucoma were associated with higher 30-minute post-injection IOP.

Conclusions:

  • Intravitreal pegcetacoplan causes a predictable, short-lived IOP elevation.
  • The IOP increase is generally transient and resolves within 30 minutes.
  • Patients with pre-existing ocular hypertension or glaucoma require careful IOP monitoring post-injection.