Humoral response to SARS-COV-2 in COVID-19-recovered patients and correlation with various factors

On exposure to SARS-CoV-2 in participants anti-SARS-CoV-2 antibodies are expected to appear as a humoral response. Furthermore, various factors affect their expression.

The aim of this study is to investigate the humoral response of COVID-19-recovered participants and correlation with duration of disease, duration of COVID positive to date of test, occupation, blood group, age group, weight, gender, and symptoms of anti-SARS-CoV-2 antibodies.

This prospective observational study was conducted at the Department of Transfusion Medicine, at a tertiary care center in North India.

Seventy-two participants were tested for anti-SARS-CoV-2 antibodies on chemiluminescent microparticle immunoassay postgetting COVID negative.

The data were analyzed using Kruskal-Wallis and Mann-Whitney test. To correlate variables such as duration of disease, duration of COVID positive to date of test of immunoglobulin G (IgG), occupation, blood group, weight, gender, symptoms, and age group Chi-square test were used.

The correlation of anti-SARS-CoV-2 antibodies with a duration of disease (P > 0.05), duration of COVID positive to date of test of IgG (P > 0.05), occupation (P > 0.05), blood group (P > 0.05), weight (P > 0.05), gender (P > 0.05), and symptoms (P > 0.05) is insignificant and whereas significant correlation with age group (P < 0.05) seen.

A significant correlation was seen in anti-SARS-COV-2 antibodies and age group. Higher antibody levels were seen in participants of the upper extreme age group (50-60 years).