Long term endocrine issues in adults born prematurely: a systematic review
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View abstract on PubMed
Summary
This summary is machine-generated.Prematurity is linked to numerous long-term endocrine issues in adulthood, including growth, thyroid, and metabolic problems. This systematic review underscores the need for ongoing health monitoring for individuals born preterm.
Area Of Science
- Endocrinology
- Public Health
- Systematic Review
Background
- Prematurity is a significant risk factor for adult chronic diseases.
- Preterm births constitute 7% of all births in Ireland, impacting adult healthcare.
- This review focuses on long-term endocrine outcomes in adults born prematurely.
Purpose Of The Study
- To synthesize evidence on long-term endocrine-related outcomes for adults born prematurely.
- To identify specific endocrine dysfunctions associated with preterm birth.
Main Methods
- Systematic review of PubMed and Web of Science databases.
- Inclusion criteria focused on adult endocrine outcomes (hypothalamic-pituitary axis, growth, thyroid, adrenal, insulin sensitivity, lipid metabolism, cardiometabolic pathology, bone health).
- Guided by PRISMA standards, 27 studies were included after screening 1,584 papers.
Main Results
- Prematurity is a significant risk factor for various adult endocrine issues.
- Associated outcomes include reduced height, hypothalamic-pituitary axis dysfunction, lower fertility, decreased bone mineral density, and increased hypothyroidism risk.
- Cardiometabolic outcomes (11/27 studies) showed links to increased diabetes risk, reduced insulin sensitivity, higher body fat, and dyslipidemia.
Conclusions
- Prematurity is associated with long-term endocrine dysfunction across multiple domains (bone, thyroid, growth, reproduction, metabolism).
- This comprehensive data highlights the necessity of long-term adult follow-up for preterm individuals.
- Early identification and management of endocrine risks are crucial for this population.
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