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Updated: Jan 11, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Direct Synthesis of α‑Amino Ketones via Photochemical Nickel-Catalyzed Acyl-Aryl Cross-Coupling
Mariana Dos S Dupim1, Gustavo Dos S Martins1, Thais G Silva1
1Instituto de Pesquisas de Produtos Naturais, Universidade Federal Do Rio de Janeiro, Rio de Janeiro 21941-599, Brazil.
Abstract:
We report a direct method for synthesizing α-amino arylketones via photochemical nickel-catalyzed acyl-aryl cross-coupling of α-amino acid-derived aldehydes with aryl bromides. The reaction proceeds efficiently under mild conditions, particularly with electron-deficient aryl bromides, and provides mechanistic insights into the competition between ketone formation and decarbonylation pathways. The protocol further enables the straightforward preparation of cathinone derivatives, highlighting its synthetic versatility and potential in medicinal and forensic chemistry.
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