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Utilizing Repetitive Transcranial Magnetic Stimulation to Improve Language Function in Stroke Patients with Chronic Non-fluent Aphasia

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Altered Functional Activation Is Associated With Speech Dysfunction in People With Multiple Sclerosis.

Katherine Hope Kenyon¹, Frederique Boonstra¹, Gustavo Noffs¹

¹Monash University, Melbourne, Victoria, Australia.

Neurobiology of Language (Cambridge, Mass.)

|November 17, 2025

Summary

This summary is machine-generated.

People with multiple sclerosis (pwMS) show altered brain activation during speech. Those with dysarthria and tremor have reduced compensatory brain activity, indicating more advanced disease and limited management options.

Keywords:

dysarthria multiple sclerosis neuroimaging neurolinguistics speech production

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Area of Science:

Neuroscience
Neurology
Speech-Language Pathology

Background:

Dysarthria is a common motor speech disorder in multiple sclerosis (MS), often linked to cerebellar dysfunction.
Understanding brain function changes in MS-related dysarthria is limited, hindering effective management strategies.

Purpose of the Study:

To investigate functional brain activation changes during speech production in people with multiple sclerosis (pwMS).
To compare activation patterns between pwMS with and without dysarthria and/or cerebellar dysfunction (action tremor).

Main Methods:

Functional magnetic resonance imaging (fMRI) was used to assess brain activity during speech tasks.
Fifty-five pwMS and 14 healthy controls participated, with MS participants categorized by dysarthria and action tremor presence.

Main Results:

pwMS exhibited poorer speech performance and reduced overall functional activation during speech preparation compared to controls.
pwMS showed increased recruitment of left Brodmann areas 45 and 46 during speech production.
Participants with both dysarthria and action tremor performed worst and had lower functional activation, suggesting reduced compensatory mechanisms in advanced MS.

Conclusions:

Multiple sclerosis leads to altered functional activation in motor speech areas.
Compensatory activation is diminished in pwMS with both dysarthria and action tremor, likely due to disease progression.
Further research is needed to develop targeted management strategies for dysarthria in pwMS.