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Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local Anesthetics: Differential Sensitivity of Nerve Fibers

Local anesthetics (LAs) block the sodium channels of nerve trunks, sensory nerve endings, and neuromuscular junctions. Although LAs can block all kinds of nerves, the sensitivity of nerve fibers differs according to nerve types and structures. LAs are known to block myelinated fibers faster than unmyelinated ones. Also, they block pain or sensory neurons at low concentrations without affecting the motor neurons involved in muscle contractions. This helps relieve labor pain without affecting the...

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Related Experiment Video

Updated: Jan 11, 2026

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Use of In Vivo Single-fiber Recording and Intact Dorsal Root Ganglion with Attached Sciatic Nerve to Examine the Mechanism of Conduction Failure

Published on: August 27, 2019

How to Interpret a Nerve Conduction Study: A Stepwise Approach

Aaron S Zelikovich¹, Gabriela Figueiredo Pucci², Jonathan Minkis¹

¹Department of Neurology, Lenox Hill Hospital, Northwell Health, New York, NY.

Neurology. Education

|November 17, 2025

Summary

No abstract available in PubMed .

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Last Updated: Jan 11, 2026

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