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Mediastinal epithelioid sarcoma: a case report.

Xianwen Hu¹, Ronghua Yu¹, Song Li¹

¹Department of Nuclear Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China.

Frontiers in Medicine

|November 17, 2025

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Epithelioid sarcoma (ES), a rare soft tissue cancer, can occur in the mediastinum. This case highlights the importance of considering ES in mediastinal tumor diagnoses, especially when initial imaging is inconclusive.

Area of Science:

Oncology
Pathology
Radiology

Background:

Epithelioid sarcoma (ES) is a rare soft tissue malignancy with uncertain differentiation.
While ES can occur in various locations, mediastinal involvement is exceptionally uncommon.
This report details a unique case of mediastinal ES in a 57-year-old female.

Keywords:

18F-FDG PET/CT computed tomography epithelioid sarcoma mediastinum

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