Rates of parent-reported allergic conditions in children at-risk of celiac disease

Area of Science:

• Immunology
• Pediatrics
• Gastroenterology

Background:

• Allergies and chronic immune-mediated conditions are rising.
• Celiac disease (CeD) is an immune-mediated condition with increasing prevalence.
• Understanding co-occurring conditions is crucial for early diagnosis and management.

Purpose of the Study:

• To investigate the frequency of parent-reported allergic conditions in children at risk for CeD.
• To determine if there is an association between allergic conditions and the development of CeD.
• To leverage data from the Celiac Disease Genomic Environmental Microbiome and Metabolomic (CDGEMM) study.

Main Methods:

• Prospective birth cohort study design.
• Inclusion of 271 children at risk for CeD in the United States.
• Analysis of parent-reported data on food protein-induced allergic proctocolitis (FPIAP), IgE-mediated food allergy, and atopic dermatitis.

Main Results:

• A high frequency of allergic conditions was observed in the overall cohort.
• 19.8% reported FPIAP, 12.5% reported IgE-mediated food allergy, and 14.7% reported atopic dermatitis.
• Among children with CeD, 21.74% had FPIAP, 8.7% had IgE-mediated food allergy, and 21.74% had atopic dermatitis. No significant association was found between allergic conditions and CeD (p > 0.35).

Conclusions:

• Parent-reported allergic conditions are widespread among children at risk for CeD.
• The study did not find a significant association between common allergic conditions and the development of celiac disease.
• Further research may explore other immune-mediated pathways or environmental factors.