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The plot thickens: A pediatric cases series on collagenous gastritis

Annemarie Rompca1, Jessica Davis2, Ryan Pitman1

  • 1Department of Gastroenterology, Hepatology and Nutrition Indiana University School of Medicine, Riley Hospital for Children Indianapolis Indiana USA.

JPGN Reports
|November 17, 2025
PubMed

Insights

Collagenous gastritis (CG) is a rare gastric disorder. This study highlights four pediatric cases, including the first reported identical twins with CG, emphasizing diagnostic and management challenges.

Area of Science:

  • Gastroenterology
  • Pediatric Gastroenterology
  • Pathology

Background:

  • Collagenous gastritis (CG) is a rare gastrointestinal disorder.
  • Characterized by subepithelial collagen deposition in the gastric mucosa.
  • Associated symptoms include anemia, abdominal pain, dyspepsia, vomiting, and weight loss.

Purpose of the Study:

  • To present four cases of pediatric collagenous gastritis.
  • To report the first known case of identical twins with collagenous gastritis.
  • To discuss the diagnostic and management difficulties associated with CG.

Main Methods:

  • Retrospective chart review.
  • Analysis of four pediatric cases diagnosed with collagenous gastritis.

Main Results:

  • All four patients presented with anemia.
  • Three patients were initially misdiagnosed with eosinophilic gastritis.
  • Most patients did not respond to conventional medication management.

Conclusions:

  • Collagenous gastritis is a rare and challenging diagnosis.
  • Effective management strategies for CG remain elusive.
  • Further research is needed to improve diagnosis and treatment outcomes.
Abstract

Keywords:
anemiacollagen depositioneosinophiliciron deficiency

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