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Related Experiment Videos

Hepatic toxicity associated with gold therapy.

M Favreau, H Tannenbaum, J Lough

    Annals of Internal Medicine
    |December 1, 1977
    PubMed
    Summary
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    Chrysotherapy for rheumatoid arthritis can rarely cause cholestatic jaundice. Prompt recognition of this gold sodium thiomalate side effect aids in avoiding unnecessary procedures.

    Area of Science:

    • Hepatology
    • Rheumatology
    • Clinical Medicine

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
    • Chrysotherapy, using gold compounds, is a treatment for RA.
    • Adverse drug reactions require careful monitoring.

    Observation:

    • Three RA patients developed jaundice post-chrysotherapy.
    • Gold sodium thiomalate doses ranged from 37.5 to 110 mg.
    • Liver function tests revealed cholestatic jaundice.

    Findings:

    • One patient showed bile stasis and thrombi in the biliary tree.
    • Another patient had hepatocyte ballooning with minimal cholestasis.
    • All patients experienced spontaneous recovery from jaundice.

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    Implications:

    • Jaundice is a rare but significant adverse effect of chrysotherapy.
    • Awareness can prevent misdiagnosis and unnecessary interventions.
    • This highlights the importance of vigilant patient monitoring during RA treatment.