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Time-restricted eating in Alzheimer's disease: TREAD pilot trial design
Susan B Racette1, Jordan A Gunning1, Danielle E Eagan2
1College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Contemporary Clinical Trials Communications
|November 17, 2025
Summary
Time-restricted eating (TRE) shows promise for improving cognitive function in individuals with mild cognitive impairment (MCI). This pilot study assessed TRE feasibility and its impact on cognitive domains and biomarkers.
Area of Science:
- Neuroscience
- Gerontology
- Metabolic Health
Background:
- Time-restricted eating (TRE) may offer neuroprotection by enhancing metabolic processes.
- Neurodegeneration and cognitive decline are significant concerns in aging populations.
Purpose of the Study:
- To assess the feasibility of a TRE intervention in adults with mild cognitive impairment (MCI).
- To gather preliminary data on cognitive function and blood biomarkers affected by TRE.
Main Methods:
- The TRE in Alzheimer's Disease (TREAD) pilot trial enrolled 30 adults (55-89 years) with MCI.
- A 12-week intervention involved a 16-hour fast and an 8-hour eating window (≥5 days/week).
- Feasibility, safety, cognitive performance, and blood biomarkers were evaluated using pre/post assessments.
Main Results:
- This section is not available in the provided abstract.
Conclusions:
- The TREAD trial provides preliminary data on TRE feasibility and potential effects in MCI.
- Findings will inform the design of larger, longer-term randomized controlled trials on TRE and cognitive trajectory.
