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Diagnostic value of platelet to high-density lipoprotein cholesterol ratio in abdominal aortic aneurysms

Xiao Du1, Jin Xu2, Shilan Zhang3

  • 1Department of Cardiology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.

Frontiers in Cardiovascular Medicine
|November 17, 2025
PubMed

Insights

The platelet-to-HDL cholesterol ratio (PHR) is a novel biomarker for abdominal aortic aneurysm (AAA). Higher PHR levels indicate AAA presence and thrombosis, suggesting its utility as a rapid diagnostic indicator.

Area of Science:

  • Cardiovascular Medicine
  • Biomarker Discovery
  • Medical Diagnostics

Background:

  • Abdominal aortic aneurysm (AAA) presents a significant mortality risk.
  • Current AAA diagnosis relies heavily on imaging, necessitating simpler screening biomarkers.
  • The platelet-to-high-density lipoprotein cholesterol ratio (PHR) reflects systemic inflammation and hypercoagulable states.

Purpose of the Study:

  • To investigate the clinical significance of the PHR as a biomarker for AAA.
  • To evaluate PHR's diagnostic and predictive value in patients with AAA, including those with thrombosis.

Main Methods:

  • A cohort study involving 156 AAA patients and 113 healthy controls.
  • Serum PHR levels were calculated using [platelet count (1,000 cells/µl) / HDL-C (mmol/L)].
  • Receiver operating characteristic (ROC) analysis and logistic regression were employed to assess predictive value and identify independent predictors.

Main Results:

  • PHR levels were significantly elevated in AAA patients compared to controls (192.35 vs. 127.00, P < 0.001).
  • PHR was even higher in AAA patients with thrombosis (220.61 vs. 161.80, P < 0.001).
  • PHR demonstrated good predictive value for AAA diagnosis (AUC = 0.805) and for AAA with thrombosis (AUC = 0.814), and was an independent predictor for both conditions.

Conclusions:

  • The PHR exhibits significant diagnostic value for abdominal aortic aneurysm.
  • PHR can function as a rapid and effective screening indicator for clinical AAA diagnosis.
  • Elevated PHR levels are associated with the presence of AAA and concomitant thrombosis.
Abstract

Keywords:
PHRabdominal aortic aneurysmdiagnostic markerhigh-density lipoprotein cholesterolplateletthrombosis

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