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Leveraging Artificial Intelligence to Transform Thoracic Radiology for Lung Nodules and Lung Cancer: Applications,
Geewon Lee1,2, Hwan-Ho Cho3, Dong Young Jeong1
1Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine.
Journal of Thoracic Imaging
|November 17, 2025
Summary
Artificial intelligence (AI) has evolved from expert systems to deep learning and transformers for medical image analysis, particularly in detecting lung nodules and cancer. Evaluating AI
Area of Science:
- Medical Imaging Analysis
- Artificial Intelligence in Radiology
- Thoracic Radiology
Background:
- Historical evolution of AI in medical image interpretation, from expert systems to data-driven methods.
- The rise of radiomics and deep learning in medical imaging.
- Adaptation of transformer architectures for medical image analysis.
Purpose of the Study:
- To review the historical progression of AI applications in medical image interpretation.
- To explore AI's role in lung nodule and lung cancer detection, characterization, and risk prediction.
- To discuss emerging AI approaches like foundation models and multimodal AI in thoracic radiology.
Main Methods:
- Literature review of AI methods applied to medical image interpretation.
- Focus on AI applications in lung nodule and lung cancer analysis.
- Exploration of foundation models, multimodal AI, and multiomic approaches.
- Discussion of methods for evaluating AI performance in real-world clinical settings.
Main Results:
- AI demonstrates effectiveness in detecting lung nodules, assessing characteristics, and predicting cancer risk.
- AI is utilized for various lung cancer clinical needs, including prognosis, mutation identification, and treatment response.
- Transformer architectures and advanced AI models show promise in medical image analysis.
Conclusions:
- AI has significantly advanced medical image interpretation, particularly in thoracic radiology.
- The continuous evolution of AI necessitates robust evaluation methods for clinical utility.
- Future directions include foundation models, multimodal AI, and multiomic integration for lung nodule and cancer analysis.

