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Published on: January 24, 2025
Syphilis, the great mimicker: an inverted diagnostic pathway that still hits the mark
Barbara Cocuroccia1, Francesca Passarelli2, Enzo Palese1
1Department of Dermatology, Istituto Dermopatico dell'Immacolata IRCCS, Dermatological Research Hospital, Rome.
Abstract:
Dear Editor, Syphilis, the "great mimicker", remains a diagnostic challenge despite reliable serologic assays and updated management guidelines. Its wide variety of clinical and dermatological manifestations often leads to misdiagnosis, especially when lesions are atypical. We present a case in which secondary syphilis was diagnosed through an inverted pathway, with histopathology preceding clinical suspicion and serologic confirmation. [...].
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