Related Experiment Video
Updated: Jan 11, 2026

Facile Preparation of 2Z,4E-Dienamides by the Olefination of Electron-deficient Alkenes with Allyl Acetate
Published on: June 21, 2017
Regioselective Radical 1,4-Difunctionalization of 1,3-Cyclohexadiene via NHC Catalysis
Yiwen Yin1, Jianquan Feng1, Liya Wang1
1Department of Chemistry, School of Science, China Pharmaceutical University, Nanjing 210009, P. R. China.
None:
1,4-Difunctionalized cyclohexane is not only a useful building block in organic synthesis but also represents an important structural motif in a wide range of bioactive molecules. Herein, we report an unprecedented NHC-catalyzed three-component radical 1,4-difuntionalization of 1,3-cyclohexadiene with readily available materials, providing a new platform for the step-economical construction of an array of useful cyclohexenyl ketones. This protocol also features high regioselectivity, mild conditions with a metal-/photocatalyst-free reaction system, and ease of late-stage functionalization.
More Related Videos
09:35Preparation of a Corannulene-functionalized Hexahelicene by CopperI-catalyzed Alkyne-azide Cycloaddition of Nonplanar Polyaromatic Units
Published on: September 18, 2016
10:10Application of Elemental Lanthanides in the Selective C-F Activation of Trifluoromethylated Benzofulvenes Providing Access to Various Difluoroalkenes
Published on: July 28, 2018
Related Concept Videos
Benzene to 1,4-Cyclohexadiene: Birch Reduction Mechanism
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
Radical Anti-Markovnikov Addition to Alkenes: Overview
Electrophilic 1,2- and 1,4-Addition of HX to 1,3-Butadiene
Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule
The hydrohalogenation of an unsymmetrical alkene can yield two haloalkane products, depending on which vinylic carbon takes up the halogen. However, one product usually predominates, where hydrogen adds to the vinylic carbon bearing the...
Regioselectivity of Electrophilic Additions-Peroxide Effect