Sarcoma: Cardiovascular and Oncologic Considerations: JACC: CardioOncology State-of-the-Art Review
Daniel S Lefler1, Elise F Nassif Haddad2, Anju Nohria3
1Abramson Cancer Center of the University of Pennsylvania, Philadelphia, Pennsylvania, USA.
JACC. Cardiooncology
|November 17, 2025
Summary
This review discusses cardiac sarcomas and the cardiotoxicity risks associated with sarcoma treatments, including anthracyclines. It emphasizes risk modification strategies and cardiac surveillance for patients undergoing sarcoma therapy.
Area of Science:
- Oncology
- Cardiology
- Tumor Biology
Background:
- Sarcomas are rare connective tissue tumors with diverse histologic subtypes.
- Cardiac sarcomas, including angiosarcoma and leiomyosarcoma, present unique challenges.
- Systemic therapies for sarcomas frequently cause cardiotoxicity.
Purpose of the Study:
- To review the unique aspects of cardiac sarcoma care.
- To discuss cardiovascular side effects of systemic sarcoma agents.
- To outline cardiac surveillance strategies for sarcoma patients.
Main Methods:
- Literature review of cardiac sarcomas and treatment-related cardiotoxicity.
- Analysis of cardiovascular risks associated with common sarcoma therapies.
- Examination of risk mitigation and surveillance protocols.
Main Results:
- Cardiac sarcomas require multimodality treatment approaches.
- Anthracyclines are a cornerstone of sarcoma treatment, necessitating cardiotoxicity risk modification.
- Various systemic agents used in sarcoma treatment carry significant cardiovascular risks.
Conclusions:
- Effective management of cardiac sarcomas involves understanding tumor biology and treatment complexities.
- Proactive cardiac surveillance and risk mitigation are essential for sarcoma patients.
- Multidisciplinary care is crucial for optimizing outcomes in patients with cardiac sarcomas.
Keywords:
anthracyclinescardiac tumorschemotherapy complicationsprimary cardiac sarcomapulmonary artery sarcomasarcomatyrosine kinase inhibitorsMore Related Videos
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