Atypical Presentation of Hepatitis A in Children
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View abstract on PubMed
Summary
This summary is machine-generated.Atypical presentations of hepatitis A virus (HAV) infection are common in children, with ascites and pleural effusion being frequent. Younger age is significantly associated with these unusual symptoms.
Area Of Science
- Pediatric Gastroenterology and Hepatology
- Infectious Diseases
- Clinical Pediatrics
Background
- Hepatitis A virus (HAV) infection typically presents with jaundice, but atypical manifestations can occur in children.
- Understanding these atypical presentations is crucial for timely diagnosis and management.
- Keywords: Ascites, Cholestasis, Hepatitis A virus, Pleural effusion, Thrombocytopenia.
Purpose Of The Study
- To determine the frequency of atypical presentations of hepatitis A virus (HAV) infection in pediatric patients.
- To identify common atypical manifestations and associated factors in children with HAV infection.
Main Methods
- A cross-sectional study was conducted involving children aged 1-18 years diagnosed with HAV infection.
- HAV infection diagnosis was based on clinical and laboratory findings, with atypical manifestations documented.
- Statistical analysis included Chi-square and t-tests/Mann-Whitney U tests (p <0.05 significance).
Main Results
- Atypical presentation of HAV infection was observed in 60 (24.4%) of 246 children.
- The most frequent atypical signs included ascites (35.0%), pleural effusion (26.7%), thrombocytopenia (21.7%), and cholestasis (15.0%).
- Younger age (p = 0.014), lower serum bilirubin (p <0.001), higher INR (p <0.001), and lower hemoglobin (p = 0.004) were associated with atypical HAV.
Conclusions
- Atypical manifestations of HAV are common in children, with ascites, pleural effusion, thrombocytopenia, and cholestasis being the most frequent.
- A younger age is significantly associated with atypical HAV manifestations.
- Distinct laboratory parameters differentiate children with atypical versus typical HAV manifestations.
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