Related Experiment Video
Updated: Jan 11, 2026
The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
Sarcopenia in Chronic Obstructive Pulmonary Disease
Sukriye Gundogdu1, Halil Ibrahim Yakar1, Handan Inonu Koseoglu1
1Department of Pulmonary Disease, Faculty of Medicine, Tokat Gaziosmanpasa University, Tokat, Turkiye.
Abstract:
Objective: To investigate the frequency of sarcopenia in patients with chronic obstructive pulmonary disease (COPD) and in the Control group, and to compare the 6-minute walk test (6MWT), handgrip strength (HGS) measured by a dynamometer, pulmonary function test (PFT) parameters, and bioimpedance analysis (BIA) parameters among the COPD GOLD A, B, and E subgroups.
Study Design:
Cohort study. Place and Duration of the Study: Department of Pulmonary Disease, Faculty of Medicine, Tokat Gaziosmanpasa University, Totak, Turkiye, from February to August 2022.
Methodology:
Sarcopenia rates were compared between the COPD group and the Control group. Patients diagnosed with COPD according to the GOLD 2022 criteria by pulmonologists were included in the COPD group. Volunteers without any neuromuscular and pulmonary disease were included in the Control group.
Results:
The study included 43 patients with COPD and 40 volunteers without respiratory disease. The incidence rate of sarcopenia was found to be 39.5% in the COPD group. Group E patients had the highest rate of sarcopenia (70%). It was found that the COPD group had lower HGS, as measured by dynamometer, and age and gender-corrected HGS measurements compared with the Control group (p = 0.019 and p = 0.005, respectively).
Conclusion:
Sarcopenia was found to be higher in the COPD group compared to the Control group. The highest rate was observed in Group E. Sarcopenia should definitely be taken into consideration in the follow-up of COPD patients, and treatment of sarcopenia (nutritional supplement, exercise, and pulmonary rehabilitation etc.) should be evaluated in those patients.
Key Words:
Chronic obstructive pulmonary disease, Sarcopenia, Inflammation, Muscle mass.
Related Concept Videos
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Inflammation
01:22Chronic Obstructive Pulmonary Disease
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...
01:25Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
01:20COPD: Pathogenesis and Clinical Features
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
01:29Chronic Obstructive Pulmonary Disease-V: Management
Smoking Cessation